A Human Ubiquitin Conjugating Enzyme (E2)-HECT E3 Ligase Structure-function Screen

Here we describe a systematic structure-function analysis of the human ubiquitin (Ub) E2 conjugating proteins, consisting of the determination of 15 new high-resolution three-dimensional structures of E2 catalytic domains, and autoubiquitylation assays for 26 Ub-loading E2s screened against a panel...

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Detalhes bibliográficos
Main Authors: Sheng, Yi, Hong, Jenny H., Doherty, Ryan, Srikumar, Tharan, Shloush, Jonathan, Avvakumov, George V., Walker, John R., Xue, Sheng, Neculai, Dante, Wan, Janet W., Kim, Sung K., Arrowsmith, Cheryl H., Raught, Brian, Dhe-Paganon, Sirano
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412965/
https://ncbi.nlm.nih.gov/pubmed/22496338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.O111.013706
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