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Circulating sclerostin is elevated in short-term and reduced in long-term SCI
Spinal cord injury (SCI) causes profound bone loss due to muscle paralysis resulting in the inability to walk. Sclerostin, a Wnt signaling pathway antagonist produced by osteocytes, is a potent inhibitor of bone formation. Short-term studies in rodent models have demonstrated increased sclerostin in...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3412894/ https://ncbi.nlm.nih.gov/pubmed/22575440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2012.04.019 |
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