Markov Models of Use-Dependence and Reverse Use-Dependence during the Mouse Cardiac Action Potential

The fast component of the cardiac transient outward current, I(Ktof), is blocked by a number of drugs. The major molecular bases of I(Ktof) are Kv4.2/Kv4.3 voltage-gated potassium channels. Drugs with similar potencies but different blocking mechanisms have differing effects on action potential dura...

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Bibliographic Details
Main Authors: Zhou, Qinlian, Bett, Glenna C. L., Rasmusson, Randall L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412869/
https://ncbi.nlm.nih.gov/pubmed/22879935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042295
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