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Improved rapid phosphotriester synthesis of oligodeoxyribonucleotides using oxygen-nucleophilic catalysts.

The use of different condensing and phosphorylating agents in conjunction with oxygen-nucleophilic catalysts, such as 4-substituted derivatives of pyridine N-oxide and quinoline N-oxide, leads to a dramatic increase of the rate of the phosphotriester bond formation and minimizes the amount of by-pro...

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Autors principals: Efimov, V A, Chakhmakhcheva, O G, Ovchinnikov YuA
Format: Artigo
Idioma:Inglês
Publicat: 1985
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC341264/
https://ncbi.nlm.nih.gov/pubmed/4011438
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