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Pharmacokinetic/Pharmacodynamic Modeling of GLP-1 in Healthy Rats
PURPOSE: To provide a mechanism-based model to quantitatively describe GLP-1 pharmacokinetics (PK) and pharmacodynamics (PD) in rats. METHODS: Intravenous (IV), infusion (IF), subcutaneous (SC), and intraperitoneal (IP) doses of GLP-1 were administered after glucose challenge in healthy Sprague–Dawl...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3412591/ https://ncbi.nlm.nih.gov/pubmed/22179928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-011-0652-x |
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