Heterozygous mutation (G/G→G/A) at nt 2607 of the EGFR gene is closely associated with increases in EGFR copy number and mRNA half life, but impaired EGFR protein synthesis in squamous cell carcinomas of the head and neck – implication for gefitinib efficacy

Gefitinib (ZD1839, Iressa(®)) is an orally active agent that inhibits the tyrosine kinase activity of epidermal growth factor receptor (EGFR). Gefitinib has shown a high efficacy in patients with non-small cell lung carcinoma and specific mutations in the ATP-binding pocket of EGFR. These mutations,...

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Main Authors: NAKAZAKI, KOUICHI, KATO, YASUMASA, TAGUCHI, TAKAHIDE, INAYAMA, YOSHIZAKI, ISHIGURO, YUKARI, KONDO, NORIO, HORIUCHI, CHOUICHI, SAKAKIBARA, ATUKO, TSUKUDA, MAMORU
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412478/
https://ncbi.nlm.nih.gov/pubmed/22870104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2010.188
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