Effect of leucovorin on the antitumor efficacy of the 5-FU prodrug, tegafur-uracil, in human colorectal cancer xenografts with various expression levels of thymidylate synthase

The combination of oral tegafur-uracil (UFT) with leucovorin (LV) is used to treat patients with stage II to III colon cancer based on the results of postoperative randomized studies in which UFT/LV treatment showed an equivalent efficacy to intravenous 5-FU plus LV therapy. However, whether the add...

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Main Authors: TSUJIMOTO, HIROAKI, TSUKIOKA, SAYAKA, ONO, SATORU, SAKAMOTO, ETSUKO, SAKAMOTO, KAZUKI, TSUTA, KOHJI, NAKAGAWA, FUMIO, SAITO, HITOSHI, UCHIDA, JUNJI, KINIWA, MAMORU, FUKUSHIMA, MASAKAZU
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412464/
https://ncbi.nlm.nih.gov/pubmed/22870097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2010.172
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