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Dopamine D1/D5 Receptors Contribute to De Novo Hippocampal LTD Mediated by Novel Spatial Exploration or Locus Coeruleus Activity

The neurons of the locus coeruleus (LC) fire in response to novelty, and LC activation coupled with hippocampal afferent stimulation leads to long-term depression (LTD). The encoding of novel spatial information also involves activation of dopamine D1/D5 receptors. It is unclear if, or how, the nora...

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Autori principali: Lemon, Neal, Manahan-Vaughan, Denise
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412443/
https://ncbi.nlm.nih.gov/pubmed/22038910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhr297
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