Signaling defects in iPSC-derived fragile X premutation neurons

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a leading monogenic neurodegenerative disorder affecting premutation carriers of the fragile X (FMR1) gene. To investigate the underlying cellular neuropathology, we produced induced pluripotent stem cell-derived neurons from isogenic subclones...

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Main Authors: Liu, Jing, Kościelska, Katarzyna A., Cao, Zhengyu, Hulsizer, Susan, Grace, Natalie, Mitchell, Gaela, Nacey, Catherine, Githinji, Jackline, McGee, Jeannine, Garcia-Arocena, Dolores, Hagerman, Randi J., Nolta, Jan, Pessah, Isaac N., Hagerman, Paul J.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412379/
https://ncbi.nlm.nih.gov/pubmed/22641815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds207
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