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The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1–dependent manner
Shiga toxin (Stx) causes diarrhea-associated hemolytic uremic syndrome by damaging renal microvascular endothelium. The pentameric B subunits of Stx types 1 and 2 (Stx1B and Stx2B) are sufficient to stimulate acute VWF secretion from endothelial cells, but Stx1B and Stx2B exert distinct effects on C...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3412335/ https://ncbi.nlm.nih.gov/pubmed/22718838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-408096 |
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