Preexisting Vaccinia Virus Immunity Decreases SIV-Specific Cellular Immunity but does not diminish Humoral Immunity and Efficacy of a DNA/MVA Vaccine

The influence of preexisting immunity to viral vectors is a major issue for the development of viral vectored vaccines. Here, we investigate the effect of preexisting vaccinia virus immunity on the immunogenicity and efficacy of a DNA/MVA SIV vaccine in rhesus macaques using a pathogenic intrarectal...

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Detalhes bibliográficos
Main Authors: Kannanganat, Sunil, Nigam, Pragati, Velu, Vijayakumar, Earl, Patricia L., Lai, Lilin, Chennareddi, Lakshmi, Lawson, Benton, Wilson, Robert L., Montefiori, David C., Kozlowski, Pamela A., Moss, Bernard, Robinson, Harriet L., Amara, Rama Rao
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412273/
https://ncbi.nlm.nih.gov/pubmed/21076059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000751
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