FGFR2 Mutation Confers a Less Drastic Gain of Function in Mesenchymal Stem Cells Than in Fibroblasts

Gain-of-function mutations in FGFR2 cause Apert syndrome (AS), a disease characterized by craniosynostosis and limb bone defects both due to abnormalities in bone differentiation and remodeling. Although the periosteum is an important cell source for bone remodeling, its role in craniosynostosis rem...

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Autori principali: Yeh, Erika, Atique, Rodrigo, Ishiy, Felipe A. A., Fanganiello, Roberto Dalto, Alonso, Nivaldo, Matushita, Hamilton, da Rocha, Katia Maria, Passos-Bueno, Maria Rita
Natura: Artigo
Lingua:Inglês
Pubblicazione: Humana Press Inc 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412083/
https://ncbi.nlm.nih.gov/pubmed/22048896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12015-011-9327-6
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