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Large mutational target size for rapid emergence of bacterial persistence

Phenotypic heterogeneity displayed by a clonal bacterial population permits a small fraction of cells to survive prolonged exposure to antibiotics. Although first described over 60 y ago, the molecular mechanisms underlying this behavior, termed persistence, remain largely unknown. To systematically...

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Detalhes bibliográficos
Main Authors: Girgis, Hany S., Harris, Kendra, Tavazoie, Saeed
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411964/
https://ncbi.nlm.nih.gov/pubmed/22802628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205124109
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