Rational design of a fluorescent NADPH derivative imaging constitutive nitric-oxide synthases upon two-photon excitation

We report the structure-based design and synthesis of a unique NOS inhibitor, called nanoshutter NS1, with two-photon absorption properties. NS1 targets the NADPH site of NOS by a nucleotide moiety mimicking NADPH linked to a conjugated push–pull chromophore with nonlinear absorption properties. Bec...

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Detalhes bibliográficos
Main Authors: Li, Yun, Wang, Huan, Tarus, Bogdan, Perez, Miguel Romero, Morellato, Laurence, Henry, Etienne, Berka, Vladimir, Tsai, Ah-Lim, Ramassamy, Booma, Dhimane, Hamid, Dessy, Chantal, Tauc, Patrick, Boucher, Jean-Luc, Deprez, Eric, Slama-Schwok, Anny
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411954/
https://ncbi.nlm.nih.gov/pubmed/22802674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205645109
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