A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity

Using chemical germ-line mutagenesis, we screened mice for defects in the humoral immune response to a type II T-independent immunogen and an experimental alphavirus vector. A total of 26 mutations that impair humoral immunity were recovered, and 19 of these mutations have been positionally cloned....

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Main Authors: Arnold, Carrie N., Pirie, Elaine, Dosenovic, Pia, McInerney, Gerald M., Xia, Yu, Wang, Nathaniel, Li, Xiaohong, Siggs, Owen M., Karlsson Hedestam, Gunilla B., Beutler, Bruce
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411946/
https://ncbi.nlm.nih.gov/pubmed/22761313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209134109
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