Carboxyamidotriazole-Orotate Inhibits the Growth of Imatinib-Resistant Chronic Myeloid Leukaemia Cells and Modulates Exosomes-Stimulated Angiogenesis

The Bcr/Abl kinase has been targeted for the treatment of chronic myelogenous leukaemia (CML) by imatinib mesylate. While imatinib has been extremely effective for chronic phase CML, blast crisis CML are often resistant. New therapeutic options are therefore needed for this fatal disease. Although m...

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Main Authors: Corrado, Chiara, Flugy, Anna Maria, Taverna, Simona, Raimondo, Stefania, Guggino, Giuliana, Karmali, Rashida, De Leo, Giacomo, Alessandro, Riccardo
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2012
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411738/
https://ncbi.nlm.nih.gov/pubmed/22879938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042310
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