A Phase I Double Blind, Placebo-Controlled, Randomized Study of a Multigenic HIV-1 Adenovirus Subtype 35 Vector Vaccine in Healthy Uninfected Adults

BACKGROUND: We conducted a phase I, randomized, double-blind, placebo-controlled trial to assess the safety and immunogenicity of escalating doses of two recombinant replication defective adenovirus serotype 35 (Ad35) vectors containing gag, reverse transcriptase, integrase and nef (Ad35-GRIN) and e...

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Hauptverfasser: Keefer, Michael C., Gilmour, Jill, Hayes, Peter, Gill, Dilbinder, Kopycinski, Jakub, Cheeseman, Hannah, Cashin-Cox, Michelle, Naarding, Marloes, Clark, Lorna, Fernandez, Natalia, Bunce, Catherine A., Hay, Christine M., Welsh, Sabrina, Komaroff, Wendy, Hachaambwa, Lottie, Tarragona-Fiol, Tony, Sayeed, Eddy, Zachariah, Devika, Ackland, James, Loughran, Kelley, Barin, Burc, Cormier, Emmanuel, Cox, Josephine H., Fast, Patricia, Excler, Jean-Louis
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411704/
https://ncbi.nlm.nih.gov/pubmed/22870265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041936
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