Exercise Training Prevents Oxidative Stress and Ubiquitin-Proteasome System Overactivity and Reverse Skeletal Muscle Atrophy in Heart Failure

BACKGROUND: Heart failure (HF) is known to lead to skeletal muscle atrophy and dysfunction. However, intracellular mechanisms underlying HF-induced myopathy are not fully understood. We hypothesized that HF would increase oxidative stress and ubiquitin-proteasome system (UPS) activation in skeletal...

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Autors principals: Cunha, Telma F., Bacurau, Aline V. N., Moreira, Jose B. N., Paixão, Nathalie A., Campos, Juliane C., Ferreira, Julio C. B., Leal, Marcelo L., Negrão, Carlos E., Moriscot, Anselmo S., Wisløff, Ulrik, Brum, Patricia C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411696/
https://ncbi.nlm.nih.gov/pubmed/22870245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041701
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