Object recognition memory and BDNF expression are reduced in young TgCRND8 mice

The TgCRND8 mouse model of Alzheimer’s disease exhibits progressive cortical and hippocampal β-amyloid accumulation, resulting in plaque pathology and spatial memory impairment by 3 months of age. We tested whether TgCRND8 cognitive function is disrupted prior to the appearance of macroscopic plaque...

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Main Authors: Francis, Beverly M., Kim, John, Barakat, Meredith E., Fraenkl, Stephan, Yücel, Yeni H., Peng, Shiyong, Michalski, Bernadeta, Fahnestock, Margaret, McLaurin, JoAnne, Mount, Howard T.J.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411544/
https://ncbi.nlm.nih.gov/pubmed/20447730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2010.04.003
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