Structural Basis for the Interaction of a Hexameric Replicative Helicase with the Regulatory Subunit of Human DNA Polymerase α-Primase

DNA polymerase α-primase (Pol-prim) plays an essential role in eukaryotic DNA replication, initiating synthesis of the leading strand and of each Okazaki fragment on the lagging strand. Pol-prim is composed of a primase heterodimer that synthesizes an RNA primer, a DNA polymerase subunit that extend...

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Hlavní autoři: Zhou, Bo, Arnett, Diana R., Yu, Xian, Brewster, Aaron, Sowd, Gregory A., Xie, Charlies L., Vila, Stefan, Gai, Dahai, Fanning, Ellen, Chen, Xiaojiang S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411022/
https://ncbi.nlm.nih.gov/pubmed/22700977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.363655
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