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A Specific Docking Site for DNA Polymerase α-Primase on the SV40 Helicase Is Required for Viral Primosome Activity, but Helicase Activity Is Dispensable

Replication of simian virus 40 (SV40) DNA, a model for eukaryotic chromosomal replication, can be reconstituted in vitro using the viral helicase (large tumor antigen, or Tag) and purified human proteins. Tag interacts physically with two cellular proteins, replication protein A and DNA polymerase α...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Huang, Hao, Zhao, Kun, Arnett, Diana R., Fanning, Ellen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963361/
https://ncbi.nlm.nih.gov/pubmed/20685648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.156240
Tagiau: Ychwanegu Tag
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