A Specific Docking Site for DNA Polymerase α-Primase on the SV40 Helicase Is Required for Viral Primosome Activity, but Helicase Activity Is Dispensable

Replication of simian virus 40 (SV40) DNA, a model for eukaryotic chromosomal replication, can be reconstituted in vitro using the viral helicase (large tumor antigen, or Tag) and purified human proteins. Tag interacts physically with two cellular proteins, replication protein A and DNA polymerase α...

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Bibliographic Details
Main Authors: Huang, Hao, Zhao, Kun, Arnett, Diana R., Fanning, Ellen
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963361/
https://ncbi.nlm.nih.gov/pubmed/20685648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.156240
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