Impact of Intravascular Hemolysis in Malaria on Liver Dysfunction: INVOLVEMENT OF HEPATIC FREE HEME OVERLOAD, NF-κB ACTIVATION, AND NEUTROPHIL INFILTRATION

We have investigated the impact of persistent intravascular hemolysis on liver dysfunction using the mouse malaria model. Intravascular hemolysis showed a positive correlation with liver damage along with the increased accumulation of free heme and reactive oxidants in liver. Hepatocytes overinduced...

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Detalhes bibliográficos
Main Authors: Dey, Sumanta, Bindu, Samik, Goyal, Manish, Pal, Chinmay, Alam, Athar, Iqbal, Mohd. Shameel, Kumar, Rahul, Sarkar, Souvik, Bandyopadhyay, Uday
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411003/
https://ncbi.nlm.nih.gov/pubmed/22696214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.341255
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