Regulation of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Activity by cCMP

Activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels is facilitated in vivo by direct binding of the second messenger cAMP. This process plays a fundamental role in the fine-tuning of HCN channel activity and is critical for the modulation of cardiac and neuronal rhythmic...

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Hlavní autoři: Zong, Xiangang, Krause, Stefanie, Chen, Cheng-Chang, Krüger, Jens, Gruner, Christian, Cao-Ehlker, Xiaochun, Fenske, Stefanie, Wahl-Schott, Christian, Biel, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410992/
https://ncbi.nlm.nih.gov/pubmed/22715094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.357129
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