TCR hypervariable regions expressed by T cells that respond to effective tumor vaccines

A major goal of immunotherapy for cancer is the activation of T cell responses against tumor-associated antigens (TAAs). One important strategy for improving antitumor immunity is vaccination with peptide variants of TAAs. Understanding the mechanisms underlying the expansion of T cells that respond...

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Autores principales: Jordan, Kimberly R., Buhrman, Jonathan D., Sprague, Jonathan, Moore, Brandon L., Gao, Dexiang, Kappler, John W., Slansky, Jill E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer-Verlag 2012
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410973/
https://ncbi.nlm.nih.gov/pubmed/22350070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-012-1217-5
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