The Importance of GLUT3 for De Novo Lipogenesis in Hypoxia-Induced Lipid Loading of Human Macrophages

Atherosclerotic lesions are characterized by lipid-loaded macrophages (foam cells) and hypoxic regions. Although it is well established that foam cells are produced by uptake of cholesterol from oxidized LDL, we previously showed that hypoxia also promotes foam cell formation even in the absence of...

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Main Authors: Li, Lu, Liu, Bo, Håversen, Liliana, Lu, Emma, Magnusson, Lisa U., Ståhlman, Marcus, Borén, Jan, Bergström, Göran, Levin, Malin C., Hultén, Lillemor Mattsson
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410913/
https://ncbi.nlm.nih.gov/pubmed/22876317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042360
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