Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways

BACKGROUND: Blockade of angiotensin II type 1 (AT(1)) receptors ameliorates brain inflammation, and reduces excessive brain interleukin-1 beta (IL-1β) production and release from cortical microglia. The aim of this study was to determine whether, in addition, AT(1) receptor blockade directly attenua...

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Bibliografiske detaljer
Main Authors: Pang, Tao, Wang, Juan, Benicky, Julius, Sánchez-Lemus, Enrique, Saavedra, Juan M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410820/
https://ncbi.nlm.nih.gov/pubmed/22642771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-102
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