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K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc
KRAS, BRAF, and PI3KCA are the most frequently mutated oncogenes in human colon cancer. To explore their effects on morphogenesis, we used the colon cancer–derived cell line Caco-2. When seeded in extracellular matrix, individual cells proliferate and generate hollow, polarized cysts. The expression...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3410422/ https://ncbi.nlm.nih.gov/pubmed/22826122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201202108 |
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