Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice

Tim-1, a type I transmembrane glycoprotein, consists of an IgV domain and a mucin domain. The IgV domain is essential for binding Tim-1 to its ligands, but little is known about the role of the mucin domain, even though genetic association of TIM-1 with atopy/asthma has been linked to the length of...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Xiao, Sheng, Brooks, Craig R., Zhu, Chen, Wu, Chuan, Sweere, Johanna M., Petecka, Sonia, Yeste, Ada, Quintana, Francisco J., Ichimura, Takaharu, Sobel, Raymond A., Bonventre, Joseph V., Kuchroo, Vijay K.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2012
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409739/
https://ncbi.nlm.nih.gov/pubmed/22773818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120914109
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