Copy number variation detection and genotyping from exome sequence data

While exome sequencing is readily amenable to single-nucleotide variant discovery, the sparse and nonuniform nature of the exome capture reaction has hindered exome-based detection and characterization of genic copy number variation. We developed a novel method using singular value decomposition (SV...

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Bibliografiska uppgifter
Huvudupphovsmän: Krumm, Niklas, Sudmant, Peter H., Ko, Arthur, O'Roak, Brian J., Malig, Maika, Coe, Bradley P., Quinlan, Aaron R., Nickerson, Deborah A., Eichler, Evan E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2012
Ämnen:
Method
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409265/
https://ncbi.nlm.nih.gov/pubmed/22585873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.138115.112
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