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Antigen shedding may improve efficiencies for delivery of antibody-based anticancer agents in solid tumors

Recombinant immunotoxins (RIT) are targeted anti-cancer agents that are composed of a targeting antibody fragment and a protein toxin fragment. SS1P is a RIT that targets mesothelin on the surface of cancer cells and is being evaluated in patients with mesothelioma. Mesothelin, like many other targe...

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Detalhes bibliográficos
Main Authors: Pak, Youngshang, Zhang, Yujian, Pastan, Ira, Lee, Byungkook
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408876/
https://ncbi.nlm.nih.gov/pubmed/22562466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3925
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