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Sample Size Re-Estimation in an On-going NIH-Sponsored Clinical Trial: The Secondary Prevention of Small Subcortical Stroke Experience

BACKGROUND AND PURPOSE: When planning clinical trials, decisions regarding sample size are often based on educated guesses of parameters, that may in fact prove to be over- or underestimates. For example, after initiation of the SPS3 study, published data indicated that the recurrent stroke rates mi...

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Hlavní autoři: McClure, Leslie A., Szychowski, Jeff M., Benavente, Oscar, Coffey, Christopher S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408857/
https://ncbi.nlm.nih.gov/pubmed/22750086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2012.06.007
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