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miR-122 regulates hepatic lipid metabolism and tumor suppression

In this issue of JCI, two independent groups describe the effects of germline and liver-specific deletion of Mir122a, the predominant liver miRNA. Their findings reveal a critical role for miR-122 in fat and cholesterol metabolism but suggest that other metabolic actions of the liver are independent...

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Autori principali: Wen, Jessica, Friedman, Joshua R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408753/
https://ncbi.nlm.nih.gov/pubmed/22820284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63966
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