Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis

Several lines of evidence suggest a link between age-related macular degeneration and retinal cholesterol maintenance. Cytochrome P450 27A1 (CYP27A1) is a ubiquitously expressed mitochondrial sterol 27-hydroxylase that plays an important role in the metabolism of cholesterol and cholesterol-related...

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Bibliographic Details
Main Authors: Omarova, Saida, Charvet, Casey D., Reem, Rachel E., Mast, Natalia, Zheng, Wenchao, Huang, Suber, Peachey, Neal S., Pikuleva, Irina A.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408752/
https://ncbi.nlm.nih.gov/pubmed/22820291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63816
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