Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism

Genome-wide association studies (GWAS) have identified a genetic variant at a locus on chromosome 1p13 that is associated with reduced risk of myocardial infarction, reduced plasma levels of LDL cholesterol (LDL-C), and markedly increased expression of the gene sortilin-1 (SORT1) in liver. Sortilin...

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Detalhes bibliográficos
Main Authors: Strong, Alanna, Ding, Qiurong, Edmondson, Andrew C., Millar, John S., Sachs, Katherine V., Li, Xiaoyu, Kumaravel, Arthi, Wang, Margaret Ye, Ai, Ding, Guo, Liang, Alexander, Eric T., Nguyen, David, Lund-Katz, Sissel, Phillips, Michael C., Morales, Carlos R., Tall, Alan R., Kathiresan, Sekar, Fisher, Edward A., Musunuru, Kiran, Rader, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408750/
https://ncbi.nlm.nih.gov/pubmed/22751103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63563
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