Subcellular Knockout of Importin β1 Perturbs Axonal Retrograde Signaling

Subcellular localization of mRNA enables compartmentalized regulation within large cells. Neurons are the longest known cells, however so far evidence is lacking for an essential role of endogenous mRNA localization in axons. Localized upregulation of importin β1 in lesioned axons coordinates a retr...

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Hlavní autoři: Perry, Rotem Ben-Tov, Doron-Mandel, Ella, Iavnilovitch, Elena, Rishal, Ida, Dagan, Shachar Y., Tsoory, Michael, Coppola, Giovanni, McDonald, Marguerite K., Gomes, Cynthia, Geschwind, Daniel H., Twiss, Jeffery L., Yaron, Avraham, Fainzilber, Mike
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408616/
https://ncbi.nlm.nih.gov/pubmed/22841314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.05.033
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