Subcellular Knockout of Importin β1 Perturbs Axonal Retrograde Signaling

Subcellular localization of mRNA enables compartmentalized regulation within large cells. Neurons are the longest known cells, however so far evidence is lacking for an essential role of endogenous mRNA localization in axons. Localized upregulation of importin β1 in lesioned axons coordinates a retr...

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Bibliografiske detaljer
Main Authors: Perry, Rotem Ben-Tov, Doron-Mandel, Ella, Iavnilovitch, Elena, Rishal, Ida, Dagan, Shachar Y., Tsoory, Michael, Coppola, Giovanni, McDonald, Marguerite K., Gomes, Cynthia, Geschwind, Daniel H., Twiss, Jeffery L., Yaron, Avraham, Fainzilber, Mike
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408616/
https://ncbi.nlm.nih.gov/pubmed/22841314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.05.033
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