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Synaptic potentiation is critical for rapid antidepressant response to ketamine in treatment-resistant major depression
BACKGROUND: Clinical evidence that ketamine, a nonselective N-methyl-D-aspartate receptor (NMDAR) antagonist, has therapeutic effects within hours in people suffering from depression suggests that modulating glutamatergic neurotransmission is a fundamental step in alleviating the debilitating sympto...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3408548/ https://ncbi.nlm.nih.gov/pubmed/22521148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2012.03.029 |
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