Synaptic potentiation is critical for rapid antidepressant response to ketamine in treatment-resistant major depression

BACKGROUND: Clinical evidence that ketamine, a nonselective N-methyl-D-aspartate receptor (NMDAR) antagonist, has therapeutic effects within hours in people suffering from depression suggests that modulating glutamatergic neurotransmission is a fundamental step in alleviating the debilitating sympto...

Full description

Saved in:
Bibliographic Details
Main Authors: Cornwell, Brian R., Salvadore, Giacomo, Furey, Maura, Marquardt, Craig A., Brutsche, Nancy E., Grillon, Christian, Zarate, Carlos A.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408548/
https://ncbi.nlm.nih.gov/pubmed/22521148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2012.03.029
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items