Recruitment Kinetics of DNA Repair Proteins Mdc1 and Rad52 but Not 53BP1 Depend on Damage Complexity

The recruitment kinetics of double-strand break (DSB) signaling and repair proteins Mdc1, 53BP1 and Rad52 into radiation-induced foci was studied by live-cell fluorescence microscopy after ion microirradiation. To investigate the influence of damage density and complexity on recruitment kinetics, wh...

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Hauptverfasser: Hable, Volker, Drexler, Guido A., Brüning, Tino, Burgdorf, Christian, Greubel, Christoph, Derer, Anja, Seel, Judith, Strickfaden, Hilmar, Cremer, Thomas, Friedl, Anna A., Dollinger, Günther
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408406/
https://ncbi.nlm.nih.gov/pubmed/22860035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041943
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