Synthesis of C-Glycoside Analogues of β-Galactosamine-(1–>4)-3-O-Methyl-D-Chiro-Inositol and Assay as Activator of Protein Phosphatases PDHP and PP2Cα

The glycan β-galactosamine-(1–4)-3-O-methyl-D-chiro-inositol, called INS-2, was previously isolated from liver as a putative second messenger-modulator for insulin. Synthetic INS-2 injected intravenously in rats is both insulin-mimetic and insulin-sensitizing. This bioactivity is attributed to allos...

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Autori principali: Hans, Sunej K., Camara, Fatoumata, Altiti, Ahmad, Sanchez, Alejandro Martin-Montalvo, Brautigan, David L., Heimark, Douglas, Larner, Joseph, Grindrod, Scott, Brown, Milton L., Mootoo, David R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408221/
https://ncbi.nlm.nih.gov/pubmed/20079654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.12.056
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