The Synthetic Cannabinoid R(+)WIN55,212-2 Augments Interferon-β Expression via Peroxisome Proliferator-activated Receptor-α

We have demonstrated that R(+)WIN55,212-2, a synthetic cannabinoid that possesses cannabimimetic properties, acts as a novel regulator of Toll-like receptor 3 (TLR3) signaling to interferon (IFN) regulatory factor 3 (IRF3) activation and IFN-β expression, and this is critical for manifesting its pro...

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Autores principales: Downer, Eric J., Clifford, Eileen, Amu, Sylvie, Fallon, Padraic G., Moynagh, Paul N.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408184/
https://ncbi.nlm.nih.gov/pubmed/22654113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.371757
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