Discovery of a Novel Allosteric Modulator of 5-HT(3) Receptors: INHIBITION AND POTENTIATION OF CYS-LOOP RECEPTOR SIGNALING THROUGH A CONSERVED TRANSMEMBRANE INTERSUBUNIT SITE

The ligand-gated ion channels in the Cys-loop receptor superfamily mediate the effects of neurotransmitters acetylcholine, serotonin, GABA, and glycine. Cys-loop receptor signaling is susceptible to modulation by ligands acting through numerous allosteric sites. Here we report the discovery of a nov...

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Detalhes bibliográficos
Main Authors: Trattnig, Sarah M., Harpsøe, Kasper, Thygesen, Sarah B., Rahr, Louise M., Ahring, Philip K., Balle, Thomas, Jensen, Anders A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408183/
https://ncbi.nlm.nih.gov/pubmed/22589534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.360370
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