Pellino 2 Is critical for Toll-like Receptor/Interleukin-1 Receptor (TLR/IL-1R)-mediated Post-transcriptional Control

Interleukin 1 receptor-associated kinase 1(IRAK1), a key molecule in TLR/IL-1R-mediated signaling, is phosphorylated, ubiquitinated, and degraded upon ligand stimulation. We and others have recently identified Pellino proteins as novel RING E3 ubiquitin ligases involved in IRAK1 polyubiquitination a...

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Detalhes bibliográficos
Main Authors: Kim, Tae Whan, Yu, Minjia, Zhou, Hao, Cui, Wei, Wang, Jianan, DiCorleto, Paul, Fox, Paul, Xiao, Hui, Li, Xiaoxia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408172/
https://ncbi.nlm.nih.gov/pubmed/22669975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.352625
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