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Enforced Presentation of an Extrahelical Guanine to the Lesion Recognition Pocket of Human 8-Oxoguanine Glycosylase, hOGG1

A poorly understood aspect of DNA repair proteins is their ability to identify exceedingly rare sites of damage embedded in a large excess of nearly identical undamaged DNA, while catalyzing repair only at the damaged sites. Progress toward understanding this problem has been made by comparing the s...

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Main Authors: Crenshaw, Charisse M., Nam, Kwangho, Oo, Kimberly, Kutchukian, Peter S., Bowman, Brian R., Karplus, Martin, Verdine, Gregory L.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408145/
https://ncbi.nlm.nih.gov/pubmed/22511791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.316497
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