Functional Consequence of Positive Selection Revealed through Rational Mutagenesis of Human Myeloperoxidase

Myeloperoxidase (MPO) is a member of the mammalian heme peroxidase (MHP) multigene family. Whereas all MHPs oxidize specific halides to generate the corresponding hypohalous acid, MPO is unique in its capacity to oxidize chloride at physiologic pH to produce hypochlorous acid (HOCl), a potent microb...

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Библиографические подробности
Главные авторы: Loughran, Noeleen B., Hinde, Sara, McCormick-Hill, Sally, Leidal, Kevin G., Bloomberg, Sarah, Loughran, Sinéad T., O’Connor, Brendan, Ó'Fágáin, Ciarán, Nauseef, William M., O’Connell, Mary J.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2012
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Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408071/
https://ncbi.nlm.nih.gov/pubmed/22355012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mss073
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