Functional Consequence of Positive Selection Revealed through Rational Mutagenesis of Human Myeloperoxidase

Myeloperoxidase (MPO) is a member of the mammalian heme peroxidase (MHP) multigene family. Whereas all MHPs oxidize specific halides to generate the corresponding hypohalous acid, MPO is unique in its capacity to oxidize chloride at physiologic pH to produce hypochlorous acid (HOCl), a potent microb...

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Detalhes bibliográficos
Main Authors: Loughran, Noeleen B., Hinde, Sara, McCormick-Hill, Sally, Leidal, Kevin G., Bloomberg, Sarah, Loughran, Sinéad T., O’Connor, Brendan, Ó'Fágáin, Ciarán, Nauseef, William M., O’Connell, Mary J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408071/
https://ncbi.nlm.nih.gov/pubmed/22355012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mss073
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