Improvement of genetic stability in lymphocytes from Fanconi anemia patients through the combined effect of α-lipoic acid and N-acetylcysteine

Fanconi Anemia (FA) is a rare genetic disorder, characterized by progressive bone marrow failure and increased predisposition to cancer. Despite being highly heterogeneous, all FA patients are hypersensitive to alkylating agents, in particular to 1,2:3,4-diepoxybutane (DEB), and to oxidative damage....

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Autors principals: Ponte, Filipa, Sousa, Rosa, Fernandes, Ana Paula, Gonçalves, Cristina, Barbot, José, Carvalho, Félix, Porto, Beatriz
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407801/
https://ncbi.nlm.nih.gov/pubmed/22591656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1172-7-28
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