The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein

BACKGROUND: Anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL) is a T cell lymphoma defined by the presence of chromosomal translocations involving the ALK tyrosine kinase gene. These translocations generate fusion proteins (e.g. NPM-ALK) with constitutive tyrosine kinas...

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Hauptverfasser: Pearson, Joel D, Mohammed, Zubair, Bacani, Julinor T C, Lai, Raymond, Ingham, Robert J
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407532/
https://ncbi.nlm.nih.gov/pubmed/22681779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-229
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