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Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITRL co-stimulation in vivo(1)

The immune suppression that characterizes human helminth infections can hinder the development of protective immunity or help reduce pathogenic inflammation. Signaling through the T cell co-stimulator GITR counteracts immune down-regulation by augmenting effector T cell responses and abrogating supp...

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Autors principals: van der Werf, Nienke, Redpath, Stephen A., Phythian-Adams, Alexander T., Azuma, Miyuki, Allen, Judith E., Maizels, Rick M., MacDonald, Andrew S., Taylor, Matthew D.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407370/
https://ncbi.nlm.nih.gov/pubmed/21705620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100834
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